• This study evaluates the effects of L-theanine, an amino acid found in green tea, on alpha waves in the brain. The study had healthy adult participants who were given either a placebo or 200 mg of L-theanine. The results showed that L-theanine significantly increased alpha wave activity in the brain, indicating a state of alert relaxation. The study concluded that L-theanine may be beneficial for promoting relaxation without causing drowsiness.

• This study investigated the effects of l-theanine, an amino acid found in green tea, on attention and reaction time response. Adult healthy participants were randomly assigned to receive either l-theanine or placebo. The results showed that l-theanine significantly improved both accuracy and reaction time in a task measuring attention and reaction time response. Furthermore, l-theanine was found to reduce heart rate and salivary immunoglobulin A levels, indicating a decrease in stress levels. These results suggest that l-theanine may be beneficial for improving attention and reaction time response in healthy individuals.

• This study investigated the effects of L-theanine, an amino acid found in green tea, on alpha-band oscillatory brain activity during a visuo-spatial attention task. The study found that L-theanine increased alpha-band activity in the occipital, parietal regions of the brain, and decreased alpha-band activity in the frontal regions of the brain, suggesting that it may reduce anxiety and stress. The results of this study suggest that L-theanine may be beneficial for improving attention and focus while reducing anxiety and stress.

• This study examined the effects of L-theanine on the release of α-brain waves in human volunteers. The study found that L-theanine increased the release of α-brain waves in the volunteers, indicating that it may have a calming effect. The study also found that the effect of L-theanine was dose-dependent, meaning that higher doses of L-theanine resulted in greater increases in α-brain wave release. The results suggest that L-theanine may be a useful supplement for reducing stress and anxiety.

• This study examined the effects of caffeine and theanine, two compounds found in tea, on mood, blood pressure, and cognitive performance. The study found that the combination of caffeine and theanine had the greatest effect on mood, with participants reporting increased alertness and reduced fatigue. The combination also had the greatest effect on cognitive performance, with participants showing improved accuracy and speed on cognitive tasks. The combination also had the greatest effect on blood pressure, with participants showing a decrease in systolic and diastolic blood pressure. The study concluded that the combination of caffeine and theanine had the greatest effect on mood, and blood pressure.

• This study provides an overview of the properties, synthesis, and isolation of L-theanine, an amino acid found in tea. It is known to have a calming effect on the body and mind, and is used in many relaxation and stress-reduction products. The article discusses the chemical structure of L-theanine, its synthesis from other amino acids, and the various methods used to isolate it from tea. It also provides an overview of the potential health benefits associated with L-theanine, including its ability to reduce stress and anxiety, improve sleep quality, and enhance cognitive performance.

• This study examined the effects of l-theanine, an amino acid found in green tea, on psychological and physiological stress responses. The results showed that l-theanine reduced stress responses in both psychological and physiological measures. Specifically, l-theanine reduced heart rate, salivary immunoglobulin A (s-IgA) levels, and self-reported feelings of stress. These findings suggest that l-theanine may be a useful tool for reducing stress and promoting relaxation.

• This study investigated the anti-stress effects of theanine, an amino acid found in green tea, on pharmacy students during their practice. The results showed that theanine had a positive correlation with decreased salivary α-amylase activity, trait anxiety, and subjective stress. This suggests that theanine can be used as a natural remedy for stress relief in pharmacy students.

• L-theanine is a unique amino acid found in green tea that has been found to have a relaxation effect in humans. In a study conducted by Juneja et al., the effects of L-theanine on relaxation were investigated. The study found that L-theanine was able to reduce both physiological and psychological stress responses in humans. Additionally, the study found that L-theanine was able to increase alpha wave activity in the brain, which is associated with relaxation. The study concluded that L-theanine has a unique ability to induce relaxation in humans.

• This study examined the effects of a hops dry extract supplement on self-reported levels of depression, anxiety, and stress in healthy young adults. The study was a randomized, placebo-controlled, double-blind, crossover pilot study. The results showed that the hops dry extract supplement was associated with a significant reduction in self-reported levels of depression, anxiety, and stress compared to the placebo. These findings suggest that hops dry extract may be a useful supplement for reducing symptoms of depression, anxiety, and stress in healthy young adults.

• This study provides new insight into the neuropharmacological activity of Humulus lupulus L., commonly known as hops. The study found that hops have a calming effect on the central nervous system, which can help reduce stress and anxiety. Additionally, hops have been found to have sedative and hypnotic effects, which can help induce sleep. The study concluded that hops can be used as a natural remedy for relaxation.

• This study compared the sedative, pre-anesthetic, and anti-anxiety effects of a hop extract to those of diazepam. The results showed that the hop extract was as effective as diazepam in reducing anxiety and providing sedation and pre-anesthetic effects. The hop extract was also found to have fewer side effects than diazepam, making it a potentially safer option for relaxation.

• This study examined the effects of non-alcoholic beer on subjective sleep quality in a university student population. The results showed that non-alcoholic beer consumption improved subjective sleep quality in the participants. The study concluded that non-alcoholic beer may be a useful tool for improving sleep quality in university students who are under stress.

• This study examines the potential health benefits of green tea and theanine, a naturally occurring amino acid found in green tea. The study found that green tea and theanine have a range of health benefits, including improved cardiovascular health, improved cognitive function, and improved relaxation. The study also found that green tea and theanine can help reduce stress and anxiety, and can help improve sleep quality. The study concluded that green tea and theanine can be beneficial for overall health and wellbeing.

• This study investigated the central depressant effects of l-theanine, an alkylamide of glutamic acid, on the central nervous system. The results showed that theanine had a significant central depressant effect, suggesting that it could be used as a relaxant to reduce anxiety and stress.

• Ashwagandha is an analgesic that soothes nervous system from pain response (Twajj et al., 1989). The powerful anti-arthritic properties (Singh et al. 1984, 1986) of Ashwagandha are now widely accepted and documented; it is furthermore found to be effective as antipyretic as well as analgesic also.
• Ashwagandha produced significant analgesic activity for a rat experiencing heat analgesia induced by hot plate method. The peak analgesic effect of Ashwagandha was recorded as 78.03 percent at 2nd hour of administration. The involvement of pain mediators; prostaglandin and 5-hydroxytryptamine in analgesic activity of Ashwagandha was studied by pretreatment with paracetamol (100 mg/kg, ip) and cyproheptadine (10 mg/kg, ip). The analgesic activity of Ashwagandha was potentiated significantly by cyproheptadine, however, paracetamol failed to exhibit any significant change in its activity, suggesting the involvement of serotonin, but not prostaglandins in the analgesic activity of Ashwagandha (Mazen et al., 1990).

• Bhattacharya et al. (1987) extracted Sitoindosides and acylsterylglucosides in Ashwagandha and tested its anti-stress properties. Active principles of Ashwagandha, for instance the sitoindosides VII-X and Withaferin-A, have been shown to have significant anti-stress activity against acute models of experimental stress.

• Archana & Namasivayam, (1999) found Ashawagandha to have similar anti-stress activity in rats. An aqueous suspension of Ashwagandha root was used at 100 mg/kg/oral dosage. The results indicate a significant increase in the plasma corticosterone level, phagocytic index and avidity index in rats subjected to cold swimming stress. In the rats pretreated with the drug, these parameters were near control values and an increase in the swimming time was observed. These results indicate that Withania somniferaused in the crude form is a potent anti-stress agent.
• The cortisol content of adrenals was reduced significantly in animals subjected to 5 h constant swimming as compared to non-swimmer group. Pretreatment with WS prevented reduction of the cortisol content of adrenals. The ascorbic acid content was also reduced significantly after 5 h of swimming as compared to the animal of non-swimmer group. Pretreatment with WS prevent reduction in ascorbic acid content which occurs after swimming stress. Thus,Withania somniferatreatment prevents, decrease of adrenal cortisol and ascorbic acid which occurs due to swimming stress.

• This study investigated the effects of Ashwagandha on the Central Nervous System, specifically its cognitive promotion proporties. Ashwagandha is a well known Ayurvedic Rasayana, and belongs to a sub-group of Rasayanas known as Medhyarasayanas. Medhya typically refers to the mind and mental/intellectual capacity. Thus, Medhya Rasayana like Ashwagandha, is used to promote intellect and memory. The cognition-promoting effect of Medhya Rasayanas is best seen in children with memory deficits, or when memory is compromised following head injury, or a prolonged illness and in old age (Singh and Udupa., 1993).

• Ashwagandha induced a calming anxiolytic effect that was comparable to the drug Lorazepam in all three standard Anxiety tests: the elevated plus-maze, social interaction and the feeding latency in an unfamiliar environment. Further, both Ashwagandha and Lorazepam, reduced rat brain levels of tribulin, an endocoid marker of clinical anxiety, when the levels were increased following administration of the anxiogenic agent, pentylenetetrazole.
• Ashwagandha also exhibited an antidepressant effect, comparable with that induced by imipramine, in two standard tests, the forced swim-induced ‘behavioral despair’ and ‘learned helplessness’ tests. The investigations support the use of Ashwagandha as a mood stabilizer in clinical conditions of anxiety and depression. (Abdel-Magied et al., 2001)

*None of these are medicinal or health claims. We do not claim to treat, diagnose or cure any diseases. All statements are reflective of the objective findings in various clinical studies.

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