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Iso-α-Acids in Beer: Role in Memory Support
Iso-α-acids, found in hops and responsible for beer's bitterness, may support memory and brain health. Early research shows they can improve short-term memory, spatial awareness, and pattern recognition, while also potentially offering neuroprotective benefits. Non-alcoholic beers like IMPOSSIBREW® now include these compounds, making them accessible without alcohol's downsides. Key points:
- What are Iso-α-Acids? Compounds from hops formed during brewing, known for their bitterness and antimicrobial properties.
- Memory Benefits: Linked to better short-term memory, processing speed, and brain health.
- Non-Alcoholic Options: Products like IMPOSSIBREW® offer iso-α-acids in alcohol-free drinks.
- Safety: Generally safe but consult a doctor if pregnant, breastfeeding, or on medication.
Research is ongoing, focusing on dosage, long-term effects, and age-specific benefits, with promising applications in cognitive health and functional beverages.
Hops and Alpha Acids Explained
Research on Memory Effects
Researchers have been diving deeper into how neural functions relate to memory, focusing on specific outcomes.
Key Findings
Studies suggest that iso-α-acids can improve several areas of memory. Regular intake has been linked to better short-term memory, spatial awareness, and pattern recognition. Some research also points to potential improvements in working memory and processing speed, though more evidence is needed to confirm these results.
Methods and Current Limitations
These findings come from controlled trials using standardised tests conducted over several months. However, there are still gaps in the research. Many studies have looked at iso-α-acids in isolation, without considering how they interact with other compounds found in beer. Questions also remain about the best dosage and delivery methods for these benefits.
Future studies should focus on long-term memory effects, explore how age impacts results - particularly in younger adults - and identify the most effective ways to consume these compounds. Researchers are also investigating non-alcoholic delivery options, aiming to provide cognitive benefits without the downsides of alcohol.
How Iso-α-Acids Affect Memory
Brain Chemistry Effects
Studies suggest that iso-α-acids influence memory by adjusting neurotransmitter activity and lowering inflammation in key areas of the brain. These actions play a role in supporting both memory formation and retention by directly affecting essential brain functions.
Working with Other Memory-Boosting Compounds
Iso-α-acids might also complement other substances known to aid cognitive function. For instance, flavonoids are linked to improving short-term memory, omega-3 fatty acids help maintain neuronal health, and B vitamins are crucial for neurotransmitter production. Iso-α-acids could provide a longer-lasting form of memory support. Researchers are exploring how these compounds might work together, highlighting the potential benefits of a balanced diet for overall brain health.
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Uses and Safety Guidelines
Sources of Iso-α-Acids
Iso-α-acids are formed when hop α-acids are isomerised during brewing. Traditional beers, especially those with a higher hop content, are rich in these compounds. Non-alcoholic beers also retain similar levels of iso-α-acids while significantly reducing alcohol content.
IMPOSSIBREW®, awarded as the UK's best non-alcoholic beer at the 2023 World Beer Awards, incorporates iso-α-acids using a unique brewing process. Their product line, including Enhanced Lager and Enhanced Pale Ale, contains less than 0.5% ABV, ensuring these compounds remain intact.
"IMPOSSIBREW® is brewed with Social Blend™, our proprietary alcohol-alternative that uses our patent-pending technology, designed to unwind." [1]
Effects Across Age Groups
Iso-α-acids may have varying effects depending on age. Research indicates that older adults could experience more noticeable cognitive and memory-related benefits. Ongoing studies are exploring these effects across different demographics, with a focus on age-related cognitive health.
Safety Information
When consuming products containing iso-α-acids, it’s important to consider specific safety guidelines:
| Population Group | Safety Recommendations |
|---|---|
| Older Adults | Speak with a healthcare provider before regular use, particularly if you have existing health conditions. |
| Pregnant/Breastfeeding Women | Avoid use unless advised by a healthcare professional. |
| Individuals on Medication | Consult a doctor if taking antidepressants or blood thinners. |
| Those with Medical Conditions | Use cautiously if you have gastrointestinal issues or high blood pressure. |
Non-alcoholic options like IMPOSSIBREW® have been well-received, with over 1,000 reviews giving an average 4.8/5 rating. Still, individual reactions can differ, so moderation is key no matter the product.
Research Outlook
Current Research Focus
Scientists are delving into how iso-α-acids interact with brain chemistry to influence memory. Recent findings suggest these compounds may play a role in supporting cognitive functions.
Researchers are studying iso-α-acids across various age groups, testing different dosages to better understand their effects. At the forefront, Dr Paul Chazot and his team at Durham University are investigating how these compounds might improve memory and support cognitive resilience. Their work highlights the potential of iso-α-acids in promoting brain health.
Here’s a snapshot of the key research areas:
| Research Focus | Description | Current Status |
|---|---|---|
| Biochemical Pathways | Exploring how iso-α-acids interact with neurotransmitters | Early findings show positive interactions |
| Long-term Effects | Assessing the impact of prolonged use | Longitudinal studies began in 2023 |
| Age-related Benefits | Measuring effectiveness across different age groups | Multiple trials are underway |
These studies are shaping the future of product development in this space.
New Product Development
The beverage industry is already applying these research insights to create functional drinks infused with iso-α-acids. These products aim to deliver the cognitive benefits highlighted by recent studies.
A great example is IMPOSSIBREW®, which launched its Enhanced Lager and Pale Ale range in March 2023. Using their proprietary Social Blend™ technology, the company has seen success, with 70% of customers reporting increased relaxation. At £3.49 per can, these beverages represent a new type of non-alcoholic functional drink.
Scientists and beverage companies are now working together to drive innovation. With growing consumer interest in cognitive health and alcohol-free options, the market for functional drinks featuring iso-α-acids is expanding quickly.
Summary
Iso-α-acids, derived from hops, are showing potential for supporting memory by influencing brain chemistry.
Research led by Dr Paul Chazot at Durham University highlights that iso-α-acids can increase brain-derived neurotrophic factor (BDNF). BDNF plays a key role in neuroplasticity and memory formation, sparking interest in their use within functional beverages.
The beverage industry has already begun applying these findings. In 2023, IMPOSSIBREW® introduced its Enhanced Lager and Pale Ale, which combine iso-α-acids with nootropics. Feedback from 70% of users suggests improved relaxation effects [1]. These developments build on earlier research into the cognitive benefits of iso-α-acids.
"Iso-α-acids have shown potential in enhancing cognitive function and memory retention, making them a promising area of research in neuroprotective strategies", says Dr Paul Chazot, Bioscience Professor and Chair of Pharmacology at Durham University.
Current studies are exploring how iso-α-acids influence neurotransmission, improve synaptic plasticity, and minimise oxidative stress. These findings suggest they could play a role in therapeutic approaches for brain health.
As research progresses, there is hope for new advancements in memory support and cognitive health, paving the way for non-alcoholic beverages that offer brain-boosting benefits without the drawbacks of alcohol.
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Find our most commonly asked questions below or ask our AI Brewer for instant answers.
What is IMPOSSIBREW®?
IMPOSSIBREW® is a pioneering non-alcoholic beer brand based in the UK that aims to create the world's most complete alcohol alternative using patent-pending technology.
Founded by Mark Wong in 2021 and working with some of the world's best professors, scientists and expert brewers, IMPOSSIBREW® specialises in expertly crafted non-alcoholic beers designed to match full ABV beers in both taste and feeling.
Product Range
IMPOSSIBREW® offers a range of enhanced non-alcoholic beers, including:
- Enhanced Lager (0.5% ABV)
- Enhanced Pale Ale (0.5% ABV)
- Limited Editions (Seasonal)
Key Benefits
The key feature that sets IMPOSSIBREW® apart is its proprietary "Social Blend™" - a combination of active botanical ingredients and nootropics using patent-pending technology* designed to recreate the relaxing effects of alcohol without the negative side effects.
Along with record-breaking quality flavour that comes from a unique process without removing alcohol.
Social Blend™ Ingredients
Developed with leading scientists in top UK universities, Social Blend™ includes:
- L-Theanine
- Ashwaghanda
- Soluble Plant Fibres
- Vitamin B1
- Various Plant Extracts.
These ingredients are chosen for their potential to boost serotonin, promote relaxation, and create a calming effect similar to the "one or two pint feeling" without hangovers.
See more details on our very own research paper, with over 1,000 participants:
- More than 70% said they felt relaxed after consuming IMPOSSIBREW®.
- 88% have reduced alcohol consumption since discovering IMPOSSIBREW®.
- 95% have told a friend about IMPOSSIBREW® after trying.
- 3/4 say that IMPOSSIBREW® is "the most complete alcohol alternative currently available on the market today".
Recognition
IMPOSSIBREW® has received several notable achievements:
- Featured on BBC's Dragons' Den
- Awarded the first and only Gold Medal in the No/Low beer category from the London Beer Competition
- Received multiple industry Gold awards in categories against Full-ABV beers
- Most followed No/Low Alcohol brand on TikTok globally.
Mission and Vision
IMPOSSIBREW® is on a mission to redefine non-alcoholic drinking by creating better-than-alcohol alternatives for those who love beer but want to avoid the health risks associated with alcohol consumption.
The company aims to become the global leading alcohol alternative brand, focusing on helping people transition to a healthier mode of relaxation without the traditional issues and side effects of alcohol.
Production and Ingredients
IMPOSSIBREW® combines traditional brewing methods with their proprietary Social Blend™ along with patent-pending technology*
The beers are made with traditional brewing ingredients such as water, malted barley, wheat, hops, and yeast, in addition to the Social Blend™ components - leveraging their unique cryogenic fermentation process, which means no alcohol is ever removed from the product - ensuring the most authentic quality taste you've come to expect.
Who is it for?
IMPOSSIBREW® caters to consumers who:
- Are busy professionals and parents who would like to unwind with a drink but don't want the hangovers.
- Enjoy the taste and relaxing experience of beer
- Are looking for healthier alternatives to alcohol, with lower calories, carbs and sugar
- Want to avoid hangovers and other negative effects of alcohol consumption
- Are interested in functional beverages with potential mood-enhancing properties
By offering a unique product that aims to replicate both the taste and feeling of alcoholic beer, IMPOSSIBREW® is positioning itself at the forefront of the growing non-alcoholic beverage market.
Get Started Today
Give it a try today with our Welcome Bundle and get 2 Free Beers with your first purchase. Get it delivered straight to your door, risk-free with our 30-day money-back guarantee.
We hope you enjoy them as much as we do and we can't wait for you to try.
*Patent pending in the UK under application number GB2415685.3
How does 'Social Blend™' work?
Social Blend™ is our proprietary alcohol alternative made from a blend of science-backed ingredients using patent-pending technology*.
Designed to replicate the sensory and social relaxing experience of drinking, minus the headaches (and bad decisions).
Developed with Dr Paul Chazot, Bioscience Professor and Chair of Pharmacology at Durham University.
Key Components and Mechanisms
- L-Theanine:
- Ashwagandha Root:
- Vitamin B1 (Thiamine):
- Various nootropic herbs:
Benefits
- Relaxation: The blend promotes a state of relaxation without the sedative effects typically associated with alcohol.
- Mental Calm: By boosting alpha brain waves and serotonin levels, it helps maintain a calm and focused mental state.
- Stress Relief: The combination of L-Theanine, Ashwagandha, and Vitamin B1 helps mitigate stress and anxiety.
- Mood Enhancement: The inclusion these ingredients and other botanicals supports mood regulation and overall positive outlook.
IMPOSSIBREW®'s Social Blend™ is a carefully crafted combination of nootropic and adaptogenic ingredients designed to offer a relaxing and mood-enhancing experience without the drawbacks of alcohol. It leverages the natural properties of its components to promote relaxation, reduce stress, and enhance mood, making it a unique alternative to traditional alcoholic beverages.
(Read our latest research paper here)
*Patent pending in the UK under application number GB2415685.3
Do you ship overseas?
We ship to the UK Mainland for free when you spend over £35
We aim to expand internationally soon - stay tuned!
If you have any queries, feel free to email: hello(@)impossibrew.co.uk
How long will it take to get my orders?
For UK mainland deliveries, normal orders processed here will take 1-3 business days to arrive, with an optional upgrade to Next Day Delivery available (12pm cut-off).
Delivery details will be provided in your confirmation email.
How is 0.5% ABV alcohol-free?
Yes, we know it's confusing. Isn't 0.5% ABV still alcoholic? Officially, 0.5% ABV is classified as Dealcoholised.
- In fact, most things we consume daily have more than 0.5% ABV
- Burger Rolls - 1.2% ABV
- Orange Juice - 0.5% ABV
- Ripe Banana - 0.5% ABV
After more than 2 years of research, we've found that the 0.5% ABV from our natural brewing process significantly increases both flavour and mouthfeel - without spiking your blood alcohol level (BAC).
Is it really gluten-free?
Yes, IMPOSSIBREW® Enhanced Lager is gluten-free. Even though it contains wheat and barley, our beers have been third-party tested to contain less than 10 parts per million (PPM) of gluten, which meets the criteria to be listed as, and labeled gluten-free.
Does it have alcohol tax?
No. While it is true that our beers don't contain alcohol, and thus don't incur UK alcohol duty, we'd like to highlight some factors here that might be helpful in reflecting the value we provide.
- One-to-One Brewing Process: At IMPOSSIBREW, we take pride in our unique brewing techniques. Unlike other non-alcoholic beers, our products are never diluted, watered-down, or have their alcohol content removed - and some even dilute their alcoholic beers up to 5x. This means that our brewing process involves the same level of craftsmanship, time, and resources as a traditional craft beer, resulting in comparable production costs.
- Effective Nootropics: In our commitment to creating the most relaxing non-alcoholic beers, we utilise only the highest quality nootropics as our active ingredients, in safe and effectives dosages. At current alcohol tax rates for a 5% ABV beer, the cost of our nootropics more than double that. Instead of contributing the amounts as tax, why not have it contribute to the product quality itself?
- Small Scale Brewing: Currently, we operate on a smaller scale, which makes us less competitive than large, commercial brewers (often +10,000x our brewing size). As a growing business, we are passionate about our mission to create unique, high-quality non-alcoholic experiences, and we truly appreciate your support. As we continue to grow and expand our production capabilities, we look forward to passing on even more savings to our valued community!
At IMPOSSIBREW, we prioritise offering our customers an enhanced, premium, non-alcoholic beer experience by combining innovative brewing techniques, quality active nootropic ingredients, and award-winning taste. While our pricing may differ from other non-alcoholic competitors, we believe that the value proposition and unique experience our beers provide are well worth it.
At the end of the day, tasting is believing. So give it a try and let us know what you think - risk-free with our IMPOSSIBREW® Guarantee.
Who shouldn't drink IMPOSSIBREW®?
It is not recommended for pregnant or breastfeeding women, those with certain medical conditions like GI disorders or hypertension, or individuals taking specific medications such as antidepressants or blood thinners. If you fall into any of these categories, it's best to consult with your doctor first.
Ashwagandha can lead to overstimulation (i.e. restlessness) if taken alongside thyroid medication.
What is your philosophy?
For thousands of years, we had only one way to unwind together. One way to let our guards down. One way to bridge the gap between who we are and who we are with others.
Not because it was perfect. But because it was all we had.
We decided that wasn't good enough.
We exist because we believe in a world where social connection doesn't demand compromise.
Where being present with others doesn't mean being absent from yourself. Where letting go doesn't mean losing control.This isn't about removing alcohol. This is about something better.
Our Social Blend™ technology isn't an accident. It's the result of questioning everything we thought we knew about social drinking. About working with scientists to understand what we're really seeking in these moments of connection. About daring to imagine something that wasn't possible before.
We believe the greatest innovations don't just solve problems - they change how we live. They make us question why we ever settled for less.
That's what we're building. Not just a drink, but a new way forward. A future where social connection comes without compromise. Where tradition meets innovation. Where science meets ritual.
This is the future of social drinking.
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